Description
Product Characteristics: FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Subcellular location: Membrane, Multi-pass membrane protein.,Inward Rectifier,ATP-sensitive inward rectifier potassium channel 15, Potassium channel, inwardly rectifying subfamily J member 15, Inward rectifier K(+) channel Kir4.2, KCNJ14, Kir4.2
Target Information: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]